This series of videos, flow charts and discussion probes provides a sequence of learning activities to help students understand that proteins and DNA are not just abstract concepts in biology textbooks. Emphasis is on the concept that DNA and proteins are crucial components of our body that affect the function of human characteristics with which students are familiar. The lesson plan is divided into two portions each with a separate probing questions, videos and flow charts. The probe questions for each section provide sparks to generate student interest and focus. The first section addresses key concepts relating to proteins, and the second section focuses on key concepts relating DNA to proteins and protein variations. Two relevant flow charts are included in each section. In the first portion, students learn about how proteins contribute to the digestion of food and how different versions of a protein can result in a characteristic such as albinism, sickle cell anemia, and hemophilia or alcohol sensitivity. In the second portion, students learn about the relationship between the genetic information in DNA and the different versions of these proteins. The discussion questions, web-based activities, and flow charts for students to complete are appropriate for a high school biology introductory unit on biological molecules or as an introduction to a unit on molecular biology. Extensive background information and more than a dozen web resource links are provided for teachers. Suggestions of options for teachers to increase the depth of the lesson are included.