Ecology Disrupted is an online, ecology-based curriculum authored by educators at The American Museum of Natural History. Bighorn Sheep, containing five lessons, is one of three units within this curriculum. The lessons are designed to support students in three-dimensional learning as they learn about human impact on bighorn sheep and, in the last lesson, design potential solutions to other specific ecological disruptions caused by humans. Students engage in scientific practices as they consider whether these populations will remain stable and the different factors that influence this stability. The lessons bundle nine performance expectations from three different NGSS topics: HS-LS2 Interdependent Relationships in Ecosystems (the perspective of this review), HS-LS3 Inheritance and Variation of Traits, and HS-ESS3 Human Impacts. Teachers are encouraged to modify the lessons and/or use parts of the unit to best meet their students’ learning goals. All of the Ecology Disrupted curriculum is explicitly aligned to the NGSS, and comes with instructional support, student handouts, extension activities, videos, and assessments. The online materials are also available as downloadable files.