The WISEngineering hydroponics project aims to help students develop their understanding of photosynthesis and cellular respiration. WISEngineering is a free online, engineering-design learning environment that scaffolds engineering design by guiding students through explicit design processes such as identifying specifications and constraints, and ideating, testing, evaluating, and refining design solutions. By using a combination of the WISE online simulation and a follow up in-classroom investigation, this article describes a lesson progression that gives students experience identifying the needs of plants as well as the experience of engineering a better hydroponic container design.