This computer simulation allows students to investigate the relationship between DNA sequences and protein structures. Additionally, this interactive activity allows students to make sense of the relationship between DNA structure and types of mutations. This lesson is designed to be done individually and the teacher has the ability to edit and assign the activity through the ITSI portal (https://itsi.portal.concord.org) This link takes you to the landing page for the Innovative Technology in Science Inquiry portal. Teachers will need to register for free to access the reviewed resource.